Sinemet CR (carbidopa/levodopa) Coupons, Discounts & Cost
Sinemet CR is a drug combining carbidopa and levodopa. One way to save money on the Sinemet CR retail cost regardless of income and insurance status is to use Sinemet CR coupons or discount cards from RXCoupons. Use this Carbidopa/Levodopa coupon at this online pharmacy and receive up to 75% off the sale price.
Sinemet CR: pharmacokinetics and pharmacodynamics
Sinemet is a drug combining carbidopa and levodopa. It helps get rid of dysphagia, hypokinesia, tremor, stiffness. Levodopa is converted into dopamine directly into the CNS. Carbidopa increases the concentration of levodopa in the CNS.
The best effect can be achieved in a week.
Levodopa is rapidly absorbed from the digestive tract. The maximum concentration is observed within 2.5-3 hours. The substance is excreted through the kidneys.
The drug is prescribed in the following cases: - Parkinson's disease; - Post-encephalitic syndrome associated with intoxication (including carbon monoxide) or cerebrovascular diseases.
When should I NOT use Sinemet CR?
The drug is contraindicated in the following cases: - Angle-closure glaucoma; - Combination therapy with MAO inhibitors; - Hypersensitivity; - Melanoma, skin diseases; - Patients aged 18 years or younger.
Patients should take the drug with caution in the following cases: - Myocardial infarction; - Lung disease (bronchial asthma, etc.); - Heart failure; - Diabetes mellitus; - Kidney failure; - Erosive and ulcerative lesions of the digestive tract; - Seizures; - Epilepsy; - Liver failure: - Lactation, pregnancy.
What should I know about Sinemet CR side effects?
The following undesirable effects may typically occur: - Arrhythmia, syncope, orthostatic reactions, phlebitis; - Anorexia, dry mouth, diarrhea, bleeding in the digestive tract, constipation, vomiting, duodenal ulcer, dyspepsia; - Anemia, leukopenia, agranulocytosis, thrombocytopenia; - Headaches, sleep disturbances (nightmares, sleeplessness), dizziness, drowsiness, delirium, paresthesia, hallucinations, agitation, confusion, depression, dementia, neuroleptic syndrome, increased libido; - Urticaria, itching, angioedema, hemorrhagic vasculitis; - Upper respiratory tract infections, dyspnea; - Sweating, rash, alopecia; - Frequent urination, urinary tract infection; - Asthenia, chest pain.
Other adverse reactions when using combinations of levodopa and carbidopa: myocardial infarction, abdominal pain, dysphagia, flatulence, bruxism, heartburn, swelling, ataxia, extrapyramidal disorders, anxiety, nervousness, memory loss, disorientation, euphoria, tremor, stupor, peripheral neuropathy, sore throat, cough, malignant melanoma, diplopia, visual impairment, mydriasis, urinary retention, urinary incontinence, priapism, fatigue, weakness, pain in lower extremities, dyspnea, agitation, leukopenia, hypokalemia, hyperuricemia, proteinuria and glucosuria.
Low doses prevent side effects that have a negative effect on the gastrointestinal tract and cardiovascular system.
How to take Sinemet CR
Sinemet CR should be taken three times a day. The maximum daily dose is 1.5 g of levodopa and 150 mg of carbidopa.
If you decide to take Sinemet CR during pregnancy, you should carefully weigh the expected benefit and the possible risk to the fetus. Breastfeeding should be discontinued if you take Sinemet CR.
Drug interactions
Do not use levodopa with antacids (the risk of side effects will be higher).
Do not use levodopa with antipsychotic agents (neuroleptics), phenothiazine, pyridoxine.
Do not use levodopa with beta-adrenomimetics (the risk of cardiac rhythm disturbances will be higher).
MAO inhibitors may cause circulatory disorders. Certain drugs used for anesthesia may cause arrhythmia.
Levodopa should not be used with tricyclic antidepressants.
Diazepam, methionine, clonidine, phenytoin may reduce the antiparkinsonian effect of levodopa.
There is an increased risk of dyskinesia and hallucinations (when levodopa is used with lithium salts).
Papaverine hydrochloride, reserpine may significantly reduce the antiparkinsonian effect of Sinemet. Arrhythmias are possible with suxamethonium. Arterial hypotension is possible with tubocurarine.
Carbidopa and levodopa combination allows reduce the dose and severity of side effects of levodopa (especially nausea, vomiting, arrhythmias). Along with this, there may be dyskinesia and mental disorders associated with levodopa.