PRISTIQ (desvenlafaxine) Coupons, Discounts & Cost

PRISTIQ (desvenlafaxine) Coupons, Discounts & Cost
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Pristiq (desvenlafaxine) Coupons, Discounts & Cost

Pristiq (desvenlafaxine) is a serotonin reuptake inhibitor used for the treatment of major depressive disorder (MDD). One way to save money on the Pristiq retail cost regardless of income and insurance status is to use Pristiq coupons or discount cards from RXCoupons. Use this Desvenlafaxine coupon at this online pharmacy and receive up to 75% off the sale price.

What is Pristiq?

Pristiq (desvenlafaxine) is a serotonin reuptake inhibitor used for the treatment of major depressive disorder (MDD). It is also safe and effective for hot flushes in postmenopausal women.

Patients with impaired renal function (severe renal insufficiency) and end stage renal disease should use reduced doses of desvenlafaxine. The recommended dose for patients with hepatic insufficiency is 50 mg per day. It is not recommended to increase the dose by over 100 mg per day.

When should I avoid Pristiq?

Pristiq is not prescribed in case of hypersensitivity to desvenlafaxine, venlafaxine hydrochloride or to any other components of Pristiq.

Pristiq is not used together with MAO inhibitors or within 14 days after discontinuation of treatment with MAO inhibitors.

Interaction with other drugs and other types of interaction

MAO inhibitors

Do not use MAO inhibitors concomitantly with desvenlafaxine or within 7 days after discontinuation of treatment with desvenlafaxine. Do not use desvenlafaxine within 14 days after discontinuation of treatment with MAO inhibitors. In addition, desvenlafaxine should not be prescribed for patients undergoing linezolid or methylene blue treatment.

Serotonergic agents

Desvenlafaxine should be used with caution in combination with other drugs that can affect serotonergic system.

NSAIDs, aspirin and warfarin

Simultaneous administration of NSAIDs or aspirin can increase the risk of bleeding. Patients taking warfarin should be carefully monitored at the beginning of treatment with Pristiq.


Patients should avoid drinking alcohol while using Pristiq.

Other drugs

Desvenlafaxine has no clinically significant effect on the metabolism of nebivolol, tolterodine, desipramine, atomoxetine, dextromethorphan, metoprolol, perphenazine.

There is no need for additional dose adjustment when using desvenlafaxine simultaneously with tamoxifen and aripiprazole.

Desvenlafaxine should not be mixed with other agents containing desvenlafaxine or venlafaxine (high risk of dose-dependent side effects).

Pristiq special instructions

Suicidal thoughts in children, adolescents and young people

Patients taking Pristiq may experience depression and suicidal thoughts. It is known that antidepressants may play an important role in increasing depression and suicidality in some patients in the early stages of treatment. These drugs increase the risk of suicidal ideation and behavior in children, adolescents and young people (aged 18 to 24) with mental disorders. Therefore, all patients who are being treated with antidepressants should be properly monitored for suicidality and unusual behavioral changes, especially during the first few months of treatment.

Anxiety, agitation, panic attacks, insomnia, irritability, aggressiveness, akathisia (psychomotor anxiety), hypomania and mania have been reported in adults and children receiving antidepressants. Your doctor may change the therapeutic regimen (including the possible withdrawal of the drug) for patients with suicidality symptoms. The dose should be lowered gradually.

A proper examination of patients with symptoms of depression should be done before starting treatment with antidepressants. It should be noted that Pristiq is not used in the treatment of bipolar depression.

Serotonin syndrome

There is a risk of potentially life-threatening serotonin syndrome when using Pristiq simultaneously with other serotonergic drugs (including triptans, tricyclic antidepressants, lithium, tramadol, tryptophan and St. John’s wort), as well as with drugs that reduce the metabolism of serotonin (including MAO inhibitors for the treatment of mental disorders, and others such as linezolid and methylene blue). Symptoms of serotonin syndrome may include excitation, hallucinations, delirium, coma, tachycardia, dizziness, sweating, hot flashes, hyperthermia, tremor, hyperreflexia, impaired coordination, seizures, nausea, vomiting, diarrhea.

How should I use Pristiq?

The recommended dose of Pristiq is 50 mg once a day, regardless of food intake. The drug should be used every day at about the same time. Tablets should be swallowed whole (do not break, crush or chew). The maximum recommended dose should not exceed 100 mg per day.

Patients with impaired renal function

The maximum recommended dose for patients with moderate renal insufficiency is 50 mg per day. The maximum recommended dose for patients with severe renal insufficiency is 50 mg every other day.

Patients with impaired hepatic function

The recommended dose for patients with moderate and severe hepatic insufficiency is 50 mg per day.

What are the possible side effects of Pristiq?

Immune system: hypersensitivity.

Metabolism: rarely – hyponatremia.

Heart: often – tachycardia, palpitations, orthostatic hypotension.

CNS: very often – insomnia, dizziness, headache; often – drowsiness, tremor, anxiety, nervousness, unusual dreams; rarely – withdrawal syndrome, hallucinations, hypomania, mania, convulsions, dystonia.

Respiratory system: rarely – epistaxis.

Digestive system: very often – nausea, dry mouth, constipation; often – vomiting, diarrhea.

Skin and subcutaneous tissues: often – rash; rarely – alopecia, angioedema, photosensitivity, Stevens-Johnson syndrome.

Kidneys and urinary tract: rarely – proteinuria, urinary retention.

General disorders: often – fatigue, asthenia, irritability, high blood pressure, weight gain, weight loss; rarely – erectile dysfunction.

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