PREMARIN Coupons, Discounts & Cost

PREMARIN Coupons, Discounts & Cost
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Premarin Coupons, Discounts & Cost

Premarin belongs to the class of drugs containing conjugated estrogens. One way to save money on the Premarin retail cost regardless of income and insurance status is to use Premarin coupons or discount cards from RXCoupons. Use our Premarin coupons at your online pharmacy and receive up to 75% off the sale price each time you refill your prescription.

Premarin pharmacological action

Premarin belongs to the class of drugs containing conjugated estrogens. It contains a mixture of natural estrogens (conjugated estrogens), which are similar to endogenous estrogens.

Premarin is used to relieve menopausal symptoms in women associated with estrogen deficiency: vasomotor disorders (including hot flashes), and urogenital symptoms (atrophic vaginitis and atrophic urethritis).

Premarin prevents the development of post-menopausal osteoporosis and reduces bone resorption (but does not stimulate bone formation).

The drug lowers blood cholesterol levels, thereby reducing the risk of cardiovascular diseases.

Premarin indications for use

Premarin is used to treat certain disorders that occur in women during menopause and after the menopause. It is used to treat vasomotor disorders caused by estrogen deficiency (hot flashes, excessive sweating), atrophic vaginitis, atrophic urethritis, hypogonadism. The drug is also effective for the prevention and treatment of osteoporosis caused by estrogen deficiency.

Premarin reduces the risk of coronary heart disease that may lead to mortality in postmenopausal women.

Premarin dosing and administration

The usual dosage is 1.25 mg per day, for 3 weeks with a break of 1 week. The therapy usually starts on the 5th day of the menstrual cycle.

If necessary, the daily dose may be increased to 3.75 mg (in case of treatment of malignant tumors).

The minimum effective dose should be used in elderly patients.

Premarin contraindications

Premarin is not used in the following cases:
– Women with known or suspected breast cancer;
– Known or suspected estrogen-dependent tumors;
– Bleeding from the genital organs of unknown origin;
– Acute thrombophlebitis and thromboembolism;
– Known or suspected pregnancy;
– Hypersensitivity to the drug.

Premarin is contraindicated during pregnancy.

Keep in mind that Premarin has no effect in preventing recurrent miscarriage.

Premarin should not be used during lactation.

The use of Premarin during pregnancy is associated with an increased risk of birth defects, increased risk of vaginal adenosis, vaginal and cervical squamous cell dysplasia and vaginal cancer.

Premarin side effects

Cardio-vascular system: deep vein thrombosis, pulmonary thromboembolism.

Reproductive system: bleeding (of varying intensity), amenorrhea.

Digestive system: nausea, vomiting, bloating, epigastric pain, cholestatic jaundice, pancreatitis.

Endocrine system: increase or reduction of body weight, breast tenderness, change in libido.

CNS: headache, dizziness, migraine, chorea.

Dermatological reactions: melasma, chloasma, alopecia, rash.

Other reactions: edema, porphyria.

Premarin overdose

Symptoms of overdose include nausea, bleeding.

Treatment: gastric lavage, symptomatic therapy.

Premarin drug interactions

If you are taking two or more drugs, they can either weaken or strengthen each other’s action. Note that you may not get the expected effect.

Rifampicin may reduce the effectiveness of Premarin.

Premarin special instructions

Before starting therapy, full examination of the patient should be carried out, including tests for blood pressure, breast examination, examination of abdominal and pelvic organs, etc.

Use Premarin with caution in patients with renal and hepatic impairment, cardiovascular disease, migraine, asthma, epilepsy, porphyria, hypercalcemia, risk of thrombosis.

Keep in mind that women with an intact uterus should use Premarin in combination with progestogen (in order to reduce the risk of endometrial hyperplasia or cancer).

Note that estrogen in higher doses increases the risk of developing breast cancer. Therefore, patients taking Premarin should check their breasts regularly.

Premarin increases the risk of thrombosis, thrombophlebitis and thromboembolism. Premarin therapy should be discontinued in case of any complications.

Premarin reception must be discontinued at least 1 month prior to the planned surgery (in order to avoid the risk of thromboembolism).

Keep in mind that Premarin is not a contraceptive. It is not used to treat disorders of the nervous system or depression.

Estrogen therapy may lead to the development of pancreatitis and other complications in patients with inherited defects in lipoprotein metabolism.

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