PERSANTINE (dipyridamole) Coupons, Discounts & Cost

PERSANTINE (dipyridamole) Coupons, Discounts & Cost
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Persantine (dipyridamole) Coupons, Discounts & Cost

Persantine (dipyridamole) is a drug from the group of phosphodiesterase inhibitors. One way to save money on the Persantine retail cost regardless of income and insurance status is to use Persantine coupons or discount cards from RXCoupons. Use this Dipyridamole coupon at this online pharmacy and receive up to 75% off the sale price.

Persantine – useful information for patients

Persantine (dipyridamole) is a drug from the group of phosphodiesterase inhibitors. Persantine dilates coronary vessels, improves myocardial tolerance to hypoxia, inhibits platelet aggregation and prevents thrombus formation. The drug improves microcirculation and reduces the perfusion of the ischemic zones.

Dipyridamole has a modulating effect on the IFN system. It improves the reduced production of interferon and increases non-specific resistance to viral infections.

Persantine indications: treatment and prevention of disorders of cerebral circulation, encephalopathy, prevention of arterial and venous thromboses, prevention of thromboembolism after surgery, prevention of placental insufficiency in complicated pregnancy, various microcirculatory disorders (in the complex therapy), prevention and treatment of influenza (as a drug that causes immunomodulation).

Precautionary measures to take with Persantine

Persantine contraindications: acute myocardial infarction, coronary artery disease, unstable angina, subaortic stenosis, decompensated heart failure, severe hypotension, severe cardiac arrhythmias, bleeding tendency, severe renal insufficiency, hypersensitivity to dipyridamole.

Persantine dosage and administration

The drug should be taken 1 hour before meal.

Prevention and treatment of thrombosis (as monotherapy or in combination with anticoagulants): 75 mg 3-6 times per day. The daily dose is 300-450 mg, if necessary – increase up to 600 mg.

Heart failure: 25-50 mg 3 times per day. The daily dose is 150-225 mg.

Coronary insufficiency: 25-50 mg 3 times a day; in severe cases – 75 mg three times a day. The daily dose is 150-200 mg.

Treatment of lower extremity arterial disease – 75 mg 3 times a day. The daily dose is 150-200 mg.

As for children, the daily dose of the drug is 5-10 mg/kg per day.

Persantine during pregnancy and breastfeeding

Persantine can be used during pregnancy only in cases of extreme necessity (especially in II and III trimesters).

How to recognize Persantine side effects

The following adverse reactions are possible during Persantine therapy: cardiac arrest, myocardial infarction (fatal in rare cases), pain in the chest, electrocardiographic disorders, arrhythmia (including sinus blockage, tachycardia, bradycardia, atrial fibrillation), syncope and cerebrovascular disease (including stroke, transient ischemic attacks, seizures). Persantine may also cause severe hypotension.

There are reports of hypersensitivity reactions such as rash, urticaria, angioedema, laryngospasm, severe bronchospasm, and anaphylactoid reactions (very rarely). There are also abdominal pain, vomiting, diarrhea, nausea, dizziness, headache, paresthesia, myalgia and swelling.

Digestive system: nausea, vomiting, diarrhea.

Cardiovascular system: when used in high doses – hypotension, flushing, tachycardia (especially while taking vasodilators).

CNS: dizziness, headache.

Allergic reactions: skin rash, urticaria.

Other reactions: myalgia; in some cases – bleeding during or after surgery.

Persantine interaction with other drugs

Drugs that reduce the acidity in stomach contents (antacids, cimetidine), and proton pump inhibitors (including omeprazole) may decrease the bioavailability of dipyridamole.

Anticoagulants, acetylsalicylic acid may enhance the antiplatelet effect of dipyridamole.

Anticholinergics can cause impaired memory in elderly patients.

Beta-blockers may lead to bradycardia and asystole in patients taking dipyridamole and beta-blockers.

Dipyridamole increases the effects of adenosine.

Dipyridamole may cause severe arterial hypotension when used with dobutamine.

Caffeine and other xanthine derivatives reduce the effectiveness of dipyridamole.

Learn about Persantine special instructions

Persantine should be used with caution in patients with arterial hypertension, recent myocardial infarction, congestive heart failure.

Storage conditions

Store in the dark place. The temperature should be not higher than 25° C.

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