Onglyza (saxagliptin) Coupons, Discounts & Cost
Onglyza is a drug available to people with diabetes. One way to save money on the Onglyza retail cost regardless of income and insurance status is to use Onglyza coupons or discount cards from RXCoupons. Use this Saxagliptin coupon at this online pharmacy and receive up to 75% off the sale price.
Pharmacologic effect and indications for Onglyza
Onglyza is a drug available to people with diabetes. The active component is saxagliptin.
Onglyza is used in the treatment of type 2 diabetes (with diet and exercise to improve glycemic control): as monotherapy; as part of combined therapy with metformin; as additional drug to the monotherapy with metformin, thiazolidinediones, sulfonylurea derivatives, insulin (including in combination with metformin); as additional drug to the combination of metformin and sulfonylureas.
What should patients know about Onglyza contraindications?
Onglyza contraindications: hypersensitivity to any component of the drug, serious hypersensitivity reactions (anaphylaxis and angioedema), type 1 diabetes, diabetic ketoacidosis, lactase deficiency and glucose-galactose malabsorption, pregnancy, lactation, patients under 18 years of age.
Precautions: renal insufficiency (moderate and severe), elderly patients, combination therapy with sulfonylureas or insulin, patients with pancreatitis (high risk of pancreatitis).
Dosage and administration
Take this drug regardless of meals. The tablets should be swallowed whole (without being chewed or crushed).
Monotherapy: the recommended dose of saxagliptin is 5 mg 1 time per day.
Combination therapy: the recommended dose of saxagliptin is 5 mg 1 time per day in combination with metformin, thiazolidinediones, sulfonylureas, insulin.
Combined therapy with metformin: the recommended dose of saxagliptin is 5 mg 1 time a day, the initial dose of metformin - 500 mg per day. Metformin dose can be slightly increased.
The missed tablet should be taken as soon as the patient remembers about it. Nevertheless, do not take a double dose of the drug within 24 h.
Onglyza in special patient groups
Patients with impaired renal function
Patients with mild renal impairment may not change the doses. Patients with moderate or severe renal impairment, as well as patients on hemodialysis should take 2.5 mg once a day. The drug should be taken after dialysis session.
Patients with hepatic impairment
Patients with abnormal liver function (mild, moderate and severe) may not change the doses.
Elderly patients
No dose adjustment is required in elderly patients. However, note that these patients may have kidney disorders.
Children
The efficacy of the drug has not been studied in patients under 18 years of age.
Combination therapy
Combination therapy with drugs such as ketoconazole, clarithromycin, indinavir, atazanavir, nelfinavir, ritonavir, saquinavir, itraconazole, nefazodone: the recommended dose of Onglyza is 2.5 mg 1 time per day.
What are the possible side effects for Onglyza?
Onglyza is not prescribed during pregnancy and breastfeeding. Doctors recommend using other drugs or stop breastfeeding.
The drug is well tolerated. In rare cases, the therapy may cause the following disorders: vomiting, gastroenteritis, headache, infectious diseases of the upper respiratory tract, infectious diseases of the genitourinary system.
If you have one or more symptoms, you should stop taking this medication.
Special instructions
Patients with impaired renal function: dose adjustment is recommended in patients with renal failure, as well as for patients on hemodialysis.
Derivatives of sulfonylurea and insulin can cause hypoglycemia. Therefore, to reduce the risk of hypoglycemia, patients should reduce the doses of sulfonylureas or insulin.
Saxagliptin therapy may lead to serious hypersensitivity reactions, including anaphylaxis and angioedema. Patients should discontinue the drug in case of serious hypersensitivity reactions.
Onglyza contains lactose. Individuals with lactase deficiency, congenital galactose intolerance and glucose-galactose malabsorption should not take this drug.
Interaction with other drugs
According to research, there is a relatively small risk of clinically significant interactions with other medications.
Dexamethasone, carbamazepine, phenobarbital, rifampin, phenytoin may reduce the concentration of saxagliptin.
Sulfonylurea derivatives may provoke hypoglycemia. You may need to reduce the dose of sulfonylurea derivatives to reduce the risk of hypoglycemia.