NORVIR (ritonavir) Coupons, Discounts & Cost

NORVIR (ritonavir) Coupons, Discounts & Cost
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Norvir (ritonavir) Coupons, Discounts & Cost

Norvir (ritonavir) is a drug from the group of antiviral agents active against HIV. One way to save money on the Norvir retail cost regardless of income and insurance status is to use Norvir coupons or discount cards from RXCoupons. Use this Ritonavir coupon at this online pharmacy and receive up to 75% off the sale price.

Pharmacological properties

Norvir (ritonavir) is a drug from the group of antiviral agents active against HIV. It is used for antiretroviral therapy (ART).

Norvir is prescribed for the treatment of HIV-1 infection (in adults and children older than 3 years of age) as part of combination therapy.

Information about Norvir contraindications

Norvir tablets have the following clinical contraindications:

  • Hypersensitivity to ritonavir or any other component of the drug;
  • Decompensated liver disease (when using ritonavir as an antiretroviral agent);
  • Pancreatitis;
  • Children under 3 years of age;
  • Combination therapy with the following medications: astemizole, bepridil, cisapride, alfuzosin, amiodarone, dronedarone, dihydroergotamine, encainide, flecainide, ergometrine, methylergometrine, ergotamine, pimozide, quinidine, terfenadine, midazolam, triazolam, voriconazole, simvastatin, lovastatin, propoxyphene, clozapine, sildenafil (when it is used to treat pulmonary hypertension), avanafil, vardenafil, fusidic acid, pethidine, piroxicam, diazepam, estazolam, flurazepam, clorazepate, colchicine;
  • Combination therapy with St John’s Wort products;
  • Combination therapy with rifabutin, when used as an antiretroviral agent at a dose of 600 mg 2 times per day;
  • Combination therapy with ritonavir and rifampicin.

Pay careful attention to the following relative contraindications:

  • Hepatitis;
  • Liver disease;
  • Mild hepatic insufficiency;
  • Severe hepatic insufficiency;
  • Organic heart disease and disorders of the cardiac conduction system;
  • Patients taking certain medications (such as verapamil or atazanavir);
  • Combination therapy with drugs for the treatment of erectile dysfunction (such as sildenafil, tadalafil);
  • Combination therapy with atorvastatin, trazodone, digoxin, ketoconazole, inhaled or nasal corticosteroids (e.g., beclomethasone, budesonide);
  • Combination therapy with indinavir (800 mg twice daily).

Norvir dosage

Norvir as an antiretroviral agent in adults: 600 mg twice daily. The daily dose is 1200 mg.

A gradual increase in dose in the initial period of treatment may help improve the tolerability of the drug. The initial dose should be at least 300 mg twice daily for the first 3 days. Do not continue Norvir treatment with a dose of 300 mg 2 times a day for more than 3 days.

Norvir as an antiretroviral agent in children (3 years and older): these patients should use ritonavir in combination with other antiviral drugs. The recommended dose for children is of 350-400 mg/m2 2 times a day. The dose should not exceed 600 mg 2 times a day.

If pediatric patients cannot tolerate the maximum daily dose due to side effects, then Norvir should be used in combination with other antiretroviral agents.

Elderly patients may not change the dose.

Ritonavir is contraindicated in patients with decompensated liver disease.

Ritonavir is contraindicated in children up to 3 years of age.

Norvir side effects

The most frequently reported adverse reactions among patients receiving monotherapy with ritonavir or using ritonavir in combination with other antiretroviral agents: disorders of the digestive system (diarrhea, nausea, vomiting, abdominal pain), disorders of the nervous system (paresthesia), fatigue, asthenic syndrome.

Digestive system: anorexia, nausea, vomiting, diarrhea, dyspepsia, bloating, laryngitis;

Nervous system, insomnia, paresthesia, dizziness, drowsiness;

Metabolism: hyperlipidemia, loss of body weight;

Musculoskeletal system: myalgia;

Respiratory system: cough, pharyngitis;

Skin: rash, itching, sweating.

Digestive disorders may be associated with dehydration, hypotension, fainting, kidney failure. In some cases, hyperglycemia can occur.

Side effects are usually severe during the first 2-3 weeks of treatment. In most cases, these side effects do not require special treatment or hospitalization. Temporary discontinuation of treatment or program with reduced doses may be recommended. In some cases, it is advisable to continue Norvir therapy with additional symptomatic treatment of disorders caused by the side effects of the drug.

Interaction with other drugs

Norvir therapy should not be combined with amiodarone, astemizole, itraconazole, ketoconazole, cisapride, bupropion, clozapine, dihydroergotamine, ergotamine, encainide, meperidine, piroxicam, propoxyphenyl, quinidine, rifabutin, terfenadine. In addition, combined use is contraindicated with such sedatives and opiates as clorazepate, flurazepam, diazepam, estazolam, midazolam, zolpidem, alprazolam (in order to avoid muscle weakness and respiratory disorders).

Drugs that reduce the effect of Norvir therapy: phenobarbital, carbamazepine, dexamethasone, phenytoin, rifampin and rifabutin. Smoking also reduces the effect of Norvir.

Patients should reduce the doses of the following drugs: clarithromycin in patients with renal failure, desipramine, and saquinavir.

Special instructions

Norvir (ritonavir) does not cure HIV-1 infection and AIDS (the risk of HIV transmission cannot be excluded). Patients using ritonavir or any other antiretroviral therapy may suffer from opportunistic infections and other complications of HIV-1 infection.

It is necessary to inform the patients about the most frequently occurring adverse events such as gastrointestinal disorders and paresthesia, which may be reduced during treatment.

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