METAGLIP (glipizide/metformin) Coupons, Discounts & Cost

METAGLIP (glipizide/metformin) Coupons, Discounts & Cost
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Metaglip (glipizide/metformin) Coupons, Discounts & Cost

Metaglip is a combined hypoglycemic agent for oral administration (glipizide + metformin). One way to save money on the Metaglip retail cost regardless of income and insurance status is to use Metaglip coupons or discount cards from RXCoupons. Use this Glipizide/Metformin coupon at this online pharmacy and receive up to 75% off the sale price.

Indications for use of Metaglip

Metaglip is a combined hypoglycemic agent for oral administration (glipizide + metformin).

Metformin reduces glucose absorption and enhances peripheral utilization of glucose. It increases tissue sensitivity to insulin, inhibits hepatic gluconeogenesis, as well as reduces the levels of low-density lipoprotein and plasma triglycerides. Metformin does not stimulate insulin secretion, and therefore does not cause hypoglycemia. Moreover, it helps stabilize or reduce body weight.

Glipizide is a sulfonylurea derivative that stimulates insulin secretion and inhibits platelet aggregation. Glipizide has fibrinolytic, lipid-lowering, and mild diuretic effects.

Metaglip is used to treat type II diabetes (when diet plan is ineffective).

When Metaglip is contraindicated

Type 1 diabetes, coma, ketoacidosis, hypersensitivity to the active ingredients.

Relative contraindications: diseases of the endocrine system that affect carbohydrate metabolism: adrenocortical insufficiency, thyroid dysfunction.

Restrictions: patients older than 65 years (it is necessary to evaluate the risk/benefit ratio due to slow metabolism), children’s age. It is not recommended to prescribe Metaglip to people who perform heavy physical work (high risk of lactate acidosis).

How to use this drug during pregnancy and lactation

Metaglip is contraindicated during pregnancy and lactation. It can be used in some cases, but only if the expected effect of the treatment is higher than the potential risk to the fetus (no adequate and well-controlled studies). Female patients should stop breastfeeding during therapy with Metaglip.

How to use Metaglip?

Use during meals: 1-2 tablets three times a day.

The highest daily dose is 6 tablets.

The highest single dose is 2 tablets.

It is necessary to continuously monitor renal function and blood glucose levels. In particular, patients should control blood glucose levels when they use Metaglip in conjunction with insulin or sulfonylurea agents (risk of hypoglycemia).

Those who use metformin for a long time should check the levels of vitamin B12 (once a year). It is necessary to determine plasma lactate concentrations at least 2 times a year.

Metaglip is not used before surgery, as well as 2 days before and after the diagnostic studies (angiography, intravenous urography, etc.).

Possible Metaglip side effects

Central and peripheral nervous system: insomnia, paresthesia, emotional lability.

Cardiovascular system: tachycardia.

Digestive system: loss of appetite, constipation, aggravation of hemorrhoids (in some cases).

Muscular system: symptoms of lactic acidosis (leg cramps).

Metabolism: hypoglycemia, lactate acidosis (drowsiness, fatigue, hypotension, respiratory failure, bradyarrhythmia, abdominal pain, hypothermia, myalgia).

Allergic reactions: dermatitis, rash.

Metformin side effects: nausea, vomiting, abdominal pain, loss of appetite, erythema, lactic acidosis.

Metaglip overdose

Overdose symptoms include hypoglycemia.

Metaglip reactions and drug interactions

Ketoconazole, cyclosporine, erythromycin may increase the concentration of Metaglip.

The drug should not be used with thiazide diuretics, calcium channel blockers, lithium agents, corticosteroids, isoniazid, sympathomimetics, niacin, phenytoin, phenothiazines, thyroid hormones.

Corticosteroids and diuretics can lead to a decrease in effectiveness of the drug (dose adjustment is required).

Miconazole and fluconazole increase the risk of hypoglycemia (up to coma).

As for combination with furosemide, it is necessary to reduce the dose of Metaglip.

Drinking alcohol during treatment improves the lactic acid concentration and increases the risk of hypoglycemia.

Metaglip special instructions

The treatment should be stopped during pregnancy and lactation (use insulin injections).

The safest way to store Metaglip is out of reach of children.

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