Gleevec (imatinib) Coupons, Discounts & Cost
Gleevec (imatinib) is an antineoplastic agent indicated for the treatment of oncological diseases in adults. One way to save money on the Gleevec (imatinib) retail cost regardless of income and insurance status is to use Gleevec coupons or discount cards from RXCoupons. Use our Imatinib coupons at your online pharmacy and receive up to 75% off the sale price each time you refill your prescription.
What is Gleevec (imatinib)?
Gleevec (imatinib) is an antineoplastic agent indicated for the treatment of oncological diseases in adults: - As monotherapy in patients with recurrent or refractory acute lymphoblastic leukemia (ALL); - In combination with chemotherapy in newly diagnosed Ph+ ALL; - Systemic mastocytosis in patients negative for D816V KIT (or with unknown KIT mutational status); - Chronic eosinophilic leukemia or hypereosinophilic syndrome; - CD117-positive gastrointestinal stromal tumors (unresectable or metastatic GIST); - CD117-positive gastrointestinal stromal tumors (adjuvant therapy); - Dermatofibrosarcoma protuberans (recurrent, unresectable or metastatic DFSP).
In addition, Gleevec is prescribed for adults and children with Ph-Chromosome-positive chronic myeloid leukemia, chronic myeloid leukemia (accelerated phases and blast crisis).
When Gleevec (imatinib) is contraindicated?
Gleevec (imatinib) is contraindicated in pregnancy and breastfeeding, in patients younger than 2 years of age, in case of hypersensitivity to the drug. Gleevec is used with caution in patients with severe renal dysfunction, severe liver disease, cardiovascular disease or risk factors for heart failure, as well as in patients on regular hemodialysis treatment.
Gleevec (imatinib) dosage instructions
Gleevec (imatinib) is best taken with food, with at least 1 cup of water. If necessary, the capsules or tablets may be dissolved in water or apple juice. The suspension should be prepared immediately before use. The dose and treatment period should be determined by your doctor (based on clinical indications).
Doses of 400 and 600 mg are taken once a day; doses of 800 mg are taken in 2 divided doses (morning and evening). Systemic mastocytosis in patients negative for D816V KIT: 400 mg per day. Systemic mastocytosis with unknown KIT mutational status: 400 mg per day. Chronic myeloid leukemia: chronic phase - 400 mg per day; acceleration phase and blast crisis - 600 mg per day. The dose may be increased up to 800 mg in case of good tolerability and absence of neutropenia, thrombocytopenia or other unwanted effects. The maximum dose for children (2 years of age) is 600 mg per day. It can be taken once or in equal parts (2 times a day). Ph+ ALL: 600 mg per day. Myelodysplastic/myeloproliferative diseases: 400 mg per day. Gastrointestinal stromal tumors: 400 mg per day. The dose may be increased to 600 or 800 mg. Adjuvant therapy in gastrointestinal stromal tumors: 400 mg per day for 36 months or more. Dermatofibrosarcoma protuberans (recurrent, unresectable or metastatic DFSP): 800 mg per day. Receiving Imatinib lasts until the termination of the clinical effect. Patients with mild, moderate or severe form of functional disorders of the liver should take the drug in a daily dose of no more than 400 mg. The dose should be reduced in case of toxic side effects. The drug should be used with particular caution in patients with severe hepatic insufficiency. The doses for elderly patients should not be corrected. Temporary suspension of therapy is required in case of neutropenia and thrombocytopenia.
Side effects of Gleevec (imatinib)
The following side effects are associated with Gleevec (imatinib): Infectious diseases: rarely - sinusitis, nasopharyngitis, herpes simplex, pneumonia, urinary tract infections, fungal infections, polyps and cysts; Hematopoiesis: very often - thrombocytopenia, neutropenia, anemia; often - febrile neutropenia, pancytopenia; rarely - lymphopenia, thrombocythemia, lymphadenopathy, eosinophilia, hemolytic anemia; Metabolism: often - anorexia; rarely - hypokalemia, hypophosphatemia, hyperuricemia, hyponatremia, hyperglycemia, hypercalcemia, hypomagnesemia; Nervous system: very often - headache; often - taste disturbance, insomnia, dizziness, paresthesia; rarely - hemorrhagic stroke, peripheral neuropathy, somnolence, migraine, tremor, depression, decreased libido, anxiety, increased intracranial pressure, optic neuritis, seizures, confusion; Cardiovascular system: rarely - hot flashes, palpitations, tachycardia, congestive heart failure, hemorrhage, pulmonary edema, angina, arrhythmias, low blood pressure, atrial fibrillation, myocardial infarction, hypertension, Raynaud's syndrome, hypotension; Respiratory system: often - shortness of breath, nosebleeds, cough; rarely - pain in the throat or larynx, pharyngitis, pulmonary fibrosis, pulmonary hemorrhage, pulmonary hypertension; Digestive system: very often - indigestion, nausea, vomiting, abdominal pain, diarrhea; often - dry mouth, flatulence, constipation, GERD, gastritis, stomatitis, gastrointestinal bleeding, ulceration of the mucous membranes of the mouth, esophagitis, gastric ulcer, pancreatitis, dysphagia, hyperbilirubinemia, hepatitis, jaundice; rarely - colitis, inflammatory bowel disease, hepatic necrosis, hepatic failure; Dermatological reactions: very often - skin rash, dermatitis, eczema; often - dry skin, itching, swelling of the face, sleep hyperhidrosis, alopecia; rarely - bruises, pustular rash, ecchymosis, urticaria, skin hyperpigmentation or hypopigmentation, exfoliative dermatitis, hypotrichosis, folliculitis, psoriasis, angioedema, Stevens-Johnson syndrome, erythema multiforme; Musculoskeletal system: very often - myalgia, arthralgia, muscle cramps and spasms, bone pain; often - swelling of the joints; rarely - arthritis, muscle weakness; Urinary system: rarely - frequent urination, hematuria, acute renal failure; Reproductive system: rarely - erectile dysfunction, gynecomastia, menorrhagia, sexual dysfunction, menstrual disorders; Other reactions: often - edema, fluid retention, weight gain, fatigue, fever; rarely - chest pain.
Gleevec (imatinib) special instructions
Gleevec therapy may only be carried out under supervision of oncologist.
It is necessary to control hematological parameters and body weight (especially in elderly patients with cardiovascular disease).
The drug can cause unwanted side effects that may affect your ability to focus and concentrate. Therefore, patients must be very careful about driving.