ESTRACE (estradiol) Coupons, Discounts & Cost
Estrace (estradiol) Coupons, Discounts & Cost
Estrace (estradiol) is a preparation for hormone replacement therapy (contains estradiol). One way to save money on the Estrace (estradiol) retail cost regardless of income and insurance status is to use Estrace (estradiol) coupons or discount cards from RXCoupons. Use our Estrace (estradiol) coupons at your online pharmacy and receive up to 75% off the sale price each time you refill your prescription.
Estrace (estradiol) pharmacological properties
Estrace (estradiol) is a preparation for hormone replacement therapy (contains estradiol). It is used in estrogen deficiency, including climacteric disorders (menopause).
Estrace (estradiol) is widely used to treat climacteric syndrome – certain disorder based on age-related changes in ovarian function. It is also used in estrogen deficiency after surgical removal of the ovaries or radiation castration. In both cases reduced endogenous estrogen levels lead to the development of hot flushes, sweating, sleep disturbances, depression, irritability, headaches, dizziness, skin atrophy, hyperesthesia of the bladder, etc. In addition, long-term effects of estrogen deficiency include osteoporosis (especially menopausal osteoporosis) and increased risk of cardiovascular disease (myocardial infarction, stroke).
Estradiol plays an important role in bone formation. It is effective against osteoporosis, especially in postmenopausal women. Estradiol reduces the incidence of fractures in postmenopausal women.
Estrace (estradiol) indications
– Estrogen deficiency in menopause and after ovariectomy (physiological, premature or menopause induced by radiation), accompanied by vasomotor disturbances (hot flashes, night sweats, migraine), urogenital disorders (dyspareunia, atrophic vulvovaginitis, urethritis), mental disorders (fatigue, sleep disturbances, depression);
– Prevention of osteoporosis and cardiovascular disease in premenopausal women;
– Alopecia (in case of hyperandrogenemia);
– Hirsutism (in case of polycystic ovary syndrome);
– Uterine inertia;
– Primary biliary cirrhosis in women;
– Uterine bleeding;
– Metastatic breast cancer in men and women (palliative therapy);
– Prostate carcinoma (palliative therapy).
Estrace (estradiol) dosage and administration
The tablets should be taken without chewing (use small amounts of liquid).
Primary and secondary estrogen deficiency: 1-2 mg 1 time per day for 3 weeks (1 week break). Typically, the therapy lasts up to 6 months. Women after hysterectomy and during postmenopausal period can start the treatment on any day of the week; menstruating patients can start the treatment on the 5th day of the menstrual cycle.
Prostate cancer: 1-2 mg 3 times a day
Metastatic breast cancer in men and women: 10 mg 3 times a day for at least 3 months.
Prevention of osteoporosis: 0.5 mg 1 time a day for 23 days, followed by a five-day break.
Estrace (estradiol) overdose
Symptoms: nausea, vomiting, uterine bleeding.
Treatment: maintenance of vital functions.
Estrace (estradiol) contraindications
– Hypersensitivity to estrogen, estradiol;
– Breast cancer (diagnosed or suspected);
– Diagnosed or suspected estrogen-dependent tumors (endometrial cancer);
– Estrogen-dependent neoplastic processes, endometriosis;
– Uterine fibroids;
– Abnormal bleeding of unknown etiology;
– Acute or chronic liver disease, liver cancer, Dubin-Johnson syndrome, Rotor syndrome;
– Congenital disorders of lipid metabolism;
– Jaundice or persistent itching during a previous pregnancy;
– Herpes during a previous pregnancy;
– Severe diabetes (insulin-dependent);
– Deep vein thrombosis, thromboembolic complications, stroke;
– Sickle cell anemia, porphyria;
– Pituitary tumors;
– Pregnancy, suspected pregnancy, lactation.
Estrace (estradiol) side effects
These symptoms are usually transient: headache, dizziness, depression, migraine, chorea, blurred vision, high blood pressure, nausea, vomiting, epigastric pain, bloating, cholestatic hepatitis, cholelithiasis, changes in libido, uterine bleeding (signs of an overdose of estradiol), endometrial hyperplasia, vaginal candidiasis, breast tenderness, edema, increased or decreased body weight, attacks of porphyria.
In rare cases, pigmented spots may appear on the face (chloasma). Other skin reactions may include: contact dermatitis, itching and redness of the skin.
Estrace (estradiol) special instructions and precautions
Note that estrogen therapy increases the risk of endometrial cancer (depending on the duration of treatment and the dose of estrogen). Therefore, it is recommended to combine estrogen therapy with progestin drugs.
Prolonged estrogen replacement therapy may increase the risk of breast cancer. However, small doses of estrogen are not associated with an increased risk of breast cancer.